Follicular mucinosis is a term that encompasses three related entities. Alopecia mucinosa, Urticaria-like follicular mucinosis, and cutaneous lymphoma related. On hair-bearing skin (e.g. scalp), overlying alopecia is notable, hence the term “ alopecia mucinosa” (see Figure 5). Plaques are often composed of densely. Alopecia mucinosa is a skin disorder that generally presents, but not exclusively, as erythematous plaques or flat patches without hair primarily on the scalp.

Author: Faushicage Kazrarr
Country: Burma
Language: English (Spanish)
Genre: Music
Published (Last): 8 April 2015
Pages: 71
PDF File Size: 2.49 Mb
ePub File Size: 15.13 Mb
ISBN: 244-6-69812-775-1
Downloads: 94750
Price: Free* [*Free Regsitration Required]
Uploader: Moogubei

Dose, frequency, and duration of therapy is indicated where mcinosa and is based on published literature. Alopecia mucinosa has been divided into the primary or idiopathic variety and the secondary type associated with cutaneous T cell lymphoma.

There was a problem providing the content you requested

The third case was a year-old male who had a single erythematous, hypoesthetic lesion on the forehead, diagnosed as folliculo-tropic mycosis fungoides in the USA, who also responded completely with rifampicin, ofloxacin, minocycline ROM treatment micinosa no recurrence over the past 1 year.

Long-term dermatologic follow up is necessary; a reasonable frequency for skin and lymph node exam is every months initially, then annually.

Histogenesis of mucin in follicular mucinosis.

For more numerous or widespread lesions, or if the patient shows no response or is intolerant to the options above, the following are first-line oral therapeutic options: Plaques are often composed of densely aggregated individual papules, many of which have a central spine. Minocycline has been used in treatment of Alopecia Mucinosa, and minocycline in ROM may be the responsible for healing in case 3: Considering the rapid and complete response to antileprosy treatment in 7 cases of Alopecia mucinosa three cases described in this paper and the four similar cases described earlier[ 10 ]it is most unlikely that the response was a natural remission of the disease.

Several lymphocytes were seen infiltrating the affected follicular infundibula. Ingrown nail Anonychia ungrouped: No serological or imaging studies are useful for establishing the diagnosis of FM. Hair nails and sweat disorders.


Folliculitis Folliculitis nares perforans Tufted folliculitis Pseudofolliculitis barbae Hidradenitis Hidradenitis suppurativa Recurrent palmoplantar hidradenitis Neutrophilic eccrine hidradenitis. Alopecia mucinosafollicular mucinosisleprosy.

Treatment based on several case reports.

Alopecia Mucinosa Responding to Antileprosy Treatment: Are we Missing Something?

Hirsutism Acquired localised generalised patterned Congenital generalised localised X-linked Prepubertal. Idiopathic follicular mucinosis on the trunk.

Starting antileprosy therapy resulted in immediate clinical response.

Given the association with CTCL, as well as much rarer associations with other hematologic malignancies e. Analysis of lesional skin for Alopceia clonality using PCR for T cell receptor[TCR] gene rearrangements should be considered in patients with known or suspected FM, but is not required for diagnosis.

Topical corticosteroids mid to high potency —response expected within 3 months Tretinoin 0. Usually, primary and acute alopecia mucinosa occurring in children resolves spontaneously. Mycosis fungoides associated follicular mucinosis on posterior scalp. Case 3 at presentation muciosa erythematous plaque on left forehead.

J Cut Med Surg. Inflammatory plaques with alopecia characterized by root sheath mucinosis. X40, B X Periodic laboratory studies i. The patient completed all six doses of ROM, and has not had alopeia in the ensuing 1 year.

Diagnosis confirmation In any subtype of FM, lesional skin polymerase chain reaction PCR based molecular testing for T-cell clonality may be positive, thereby suggesting monoclonality of the infiltrating T lymphocytes. Vanessa Ngan, Staff Writer, Clonal FM may regress completely.

Alopecia Mucinosa Responding to Antileprosy Treatment: Are we Missing Something?

Follicular mucinosis as a finding has been recorded as an additional histological marker in type 1 reactional state in borderline leprosy. Journal List Indian J Dermatol v.

J Am Acad Dermatol. Two children, a boy aged 14 years and mucinoea girl aged 12 years presented themselves, each, with a single hypopigmented, hypoesthetic patch on the face. Contraindicated in patients with glucosephosphate dehydrogenase deficiency. Please review our privacy policy. Intralesional corticosteroids or excision should be considered for refractory or localized lesions, where cosmetically acceptable. Discontinue therapy or consider slow titration over months or years after complete response is evident.

Alopecia mucinosa – Wikipedia

Single lesion Alopecia mucinosa in children and young adults responds rapidly and completely with antileprosy treatment.


He too responded completely within 3 months with rifampicin, ofloxacin, minocycline ROM treatment, which was given once monthly for a total of 6 months and remains free of disease since the past 1 year. Expected results of diagnostic studies Skin biopsies are required for diagnosis.

Hydroxychloroquine mg orally, three times daily for 10 days, followed by mg orally, twice daily; response noted within 6 months, begin taper after lesions have cleared. And are there other choices? Powered By Decision Support in Medicine. These lesions, however, are always single and show rapid and complete response to antileprosy treatment. National Center for Biotechnology InformationU. This is in contrast to cases of Alopecia mucinosa reported in literature including the first report of six muciinosa by Pinkus[ 3 ] in which multiple erythematous papules and plaques occur over the head and neck region.

The skin lesion and hair loss had been present for about 3 months and was gradually progressive.

With loss of the follicle, alopecia may be evident clinically. Some papers[ 411 ] have shown good response of follicular mucinosis to minocycline, however, contrary results with very minimal or no improvement has also been reported in patients with Alopecia mucinosa who mucinowa treated with minocycline for more than 3 months.

Paronychia Acute Chronic Chevron nail Congenital onychodysplasia of the index fingers Green nails Half and half nails Hangnail Hapalonychia Hook nail Ingrown nail Lichen planus of the nails Longitudinal erythronychia Malalignment of the nail alopeciz Median nail dystrophy Mucniosa lines Melanonychia Muehrcke’s lines Nail—patella syndrome Onychoatrophy Onycholysis Onychomadesis Onychomatricoma Onychomycosis Onychophosis Onychoptosis defluvium Onychorrhexis Onychoschizia Platonychia Pincer nails Plummer’s nail Psoriatic nails Pterygium inversum unguis Pterygium unguis Purpura of the nail bed Racquet nail Red lunulae Shell nail syndrome Splinter hemorrhage Spotted lunulae Staining of the nail plate Stippled nails Subungual hematoma Terry’s nails Twenty-nail dystrophy.